Question

Increase in the solubility of the aqueous systems by adding large amount of additives is known as.........

• A. Solubilization
• B. Hydrotrophy
• C. Co solvency
• D. Solid dispersion

Hint:

Hydrotrophy involves using large quantities of hydrotropic agents (like sodium benzoate) to increase drug solubility without forming micelles.

Answer 1

The Correct Option is B

In the context of pharmaceutical sciences, the increase in solubility of aqueous systems by adding a large amount of additives is referred to as "Hydrotrophy." Hydrotrophy involves the addition of a hydrotropic agent, which is a compound that can enhance the solubility of poorly soluble substances by means of a bulk effect—quite distinct from traditional surfactant action, as no micelle formation is involved. The mechanism involves complex formation or changes in water structure that assist in dissolving compounds that otherwise remain less soluble. 

Term	Definition
Solubilization	Process of increasing solubility using surfactants forming micelles.
Hydrotrophy	Increase of solubility by large amounts of additives without forming micelles.
Co solvency	Use of co-solvents to enhance solubility of a solute.
Solid dispersion	Solid-state dispersion of a compound in a carrier matrix to improve solubility.

Directly related to applications in drug formulation and delivery, hydrotrophic agents are primarily used to facilitate higher dosages in liquid formulations where the active pharmaceutical ingredient (API) shows low solubility in water.