Question

Increase in the solubility of the aqueous systems by adding large amount of additives is known as.........

• A. Solubilization
• B. Hydrotrophy
• C. Co solvency
• D. Solid dispersion

Hint:

Hydrotrophy involves using large quantities of hydrotropic agents (like sodium benzoate) to increase drug solubility without forming micelles.

Answer 1

The Correct Option is B

Hydrotrophy is a phenomenon where the solubility of poorly water-soluble compounds is enhanced by the addition of large amounts of additives known as hydrotropic agents. These agents increase solubility by forming weak interactions with the solute without forming micelles, as is the case with surfactants. This is distinct from solubilization (which involves micelles), co-solvency (which involves miscible solvents), and solid dispersion (which is a solid-state method to enhance solubility).