Question

In Rheumatoid arthritis, which type of cells are prominently present ?

• A. B cells
• B. T cells
• C. Macrophages
• D. endritic cells

Answer 1

The Correct Option is C

In Rheumatoid arthritis, the immune system mistakenly attacks the joints, leading to inflammation and damage. The process involves various immune cells, but one of the key players in this inflammatory response are macrophages.

Here's a detailed explanation:

1. Role of Macrophages: Macrophages are a type of white blood cell that plays a critical role in the immune system. They are involved in detecting, engulfing, and destroying pathogens and apoptotic cells.

2. Presence in Inflammation: In the context of rheumatoid arthritis, macrophages are prominently present in the synovial membrane, where they release pro-inflammatory cytokines such as TNF-alpha (Tumor Necrosis Factor-alpha) and interleukins (like IL-1, IL-6).

3. Cytokine Release: The release of these cytokines contributes to inflammation and tissue damage in the joints, perpetuating the symptoms of rheumatoid arthritis.

4. Therapeutic Targeting: Because of their role in the inflammation process, macrophages and the cytokines they release have become critical targets for therapeutic interventions in the treatment of rheumatoid arthritis, such as in the use of TNF inhibitors.

Therefore, among the given options, Macrophages are the type of cells prominently present in rheumatoid arthritis, involved in driving the inflammatory process.