Question

In a patient with rice water diarrhea, which will be involved?

• A. GM1 ganglioside
• B. GM2 ganglioside
• C. Both A and B
• D. None of the above

Hint:

GM1 ganglioside is the key receptor involved in cholera toxin binding, leading to the secretion of water and electrolytes in the intestines.

Answer 1

The Correct Option is A

In rice water diarrhea, which is commonly associated with cholera, the bacteria Vibrio cholerae produces toxins that affect the GM1 ganglioside receptor on the intestinal cells. The toxin increases cyclic AMP levels in enterocytes, leading to massive secretion of water and electrolytes, causing the characteristic rice water stool. GM2 ganglioside is not involved in this process.