To solve this question, we need to identify the significant contribution made by Edward Jenner in 1798. Let's evaluate the provided options:
Based on this analysis, the correct answer is Vaccination. Edward Jenner's publication in 1798 concerning the smallpox vaccine was a groundbreaking achievement in medicine.
A fruit farmer presents with fever, respiratory difficulties, and neurological complications. What is the most likely diagnosis? 
Which of the following vaccines is kept at the lowest level? 
Choose the correct match of laxative and its Mechanism of Action (MOA):

Match the following:
(P) Schedule H
(Q) Schedule G
(R) Schedule P
(S) Schedule F2
Descriptions:
(I) Life period of drugs
(II) Drugs used under RMP
(III) List of Prescription Drugs
(IV) Standards for surgical dressing