Step 1: Differentiate $y$ with respect to $t$.
\[
y = 4t $\Rightarrow$ \frac{dy}{dt} = 4
\]
Step 2: Differentiate $x$ with respect to $t$.
\[
x = \frac{4}{t} $\Rightarrow$ \frac{dx}{dt} = -\frac{4}{t^{2}}
\]
Step 3: Apply the chain rule.
\[
\frac{dy}{dx} = \frac{\frac{dy}{dt}}{\frac{dx}{dt}} = \frac{4}{-\frac{4}{t^{2}}} = -t^{2}
\]
Step 4: Conclusion.
The correct answer is (A) $-t^{2}$.