Step 1: Understand the multiples.
We are given that:
- \( x \) is a multiple of 4, so \( x = 4k \) for some integer \( k \).
- \( y \) is a multiple of 6, so \( y = 6m \) for some integer \( m \).
Thus, the product \( xy \) is:
\[
xy = (4k)(6m) = 24km
\]
This shows that \( xy \) is always a multiple of 24, which is divisible by 8, 12, and 18.
Step 2: Check each condition.
- \( xy \) is divisible by 8, because \( 24 \) is divisible by 8.
- \( xy \) is divisible by 12, because \( 24 \) is divisible by 12.
- \( xy \) is divisible by 18, because \( 24 \) is divisible by 18.
Thus, \( xy \) is a multiple of 8, 12, and 18.
\[
\boxed{I, II, \text{and} III}
\]