To evaluate the determinant, expand and simplify:
The determinant is:
\[ \Delta = \begin{vmatrix} p & p^2 & 1 + p^3 \\ q & q^2 & 1 + q^3 \\ r & r^2 & 1 + r^3 \end{vmatrix}. \]
Using the property of determinants, subtract the first column from the second and the third column from the first, simplifying the matrix to:
\[ \Delta = \begin{vmatrix} p & p(p - 1) & p^3(p - 1) \\ q & q(q - 1) & q^3(q - 1) \\ r & r(r - 1) & r^3(r - 1) \end{vmatrix}. \]
Factor out \(p - 1\), \(q - 1\), and \(r - 1\) from the columns:
\[ \Delta = (p - 1)(q - 1)(r - 1) \begin{vmatrix} p & p^2 & 1 \\ q & q^2 & 1 \\ r & r^2 & 1 \end{vmatrix}. \]
The remaining determinant simplifies using standard properties of symmetric determinants:
\[ \begin{vmatrix} p & p^2 & 1 \\ q & q^2 & 1 \\ r & r^2 & 1 \end{vmatrix} = (q - p)(r - p)(r - q). \]
Thus, the overall value of the determinant becomes:
\[ \Delta = (1 + pqr)(q - p)(r - p)(r - q). \]
Hence, the correct answer is \((1 + pqr)(q - p)(r - p)(r - q)\).
Let \[ f(x)=\int \frac{7x^{10}+9x^8}{(1+x^2+2x^9)^2}\,dx \] and $f(1)=\frac14$. Given that 
Rearrange the following parts to form a meaningful and grammatically correct sentence:
P. a healthy diet and regular exercise
Q. are important habits
R. that help maintain good physical and mental health
S. especially in today's busy world