Question:

If Adenine makes $30 \%$ of the DNA molecule, what will be the percentage of Thymine, Guanine and Cytosine in it?

Updated On: Nov 13, 2025
  • $T : 20 ; G : 30 ; C : 20$
  • $T : 20 ; G : 20 ; C : 30$
  • $T : 30 ; G : 20 ; C : 20$
  • $T : 20 ; G : 25 ; C : 25$
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The Correct Option is C

Solution and Explanation

To determine the percentage of Thymine (T), Guanine (G), and Cytosine (C) in a DNA molecule where Adenine (A) makes up 30%, we need to understand the base pairing rules of DNA. 

  1. In DNA, Adenine (A) pairs with Thymine (T), and Guanine (G) pairs with Cytosine (C). This is known as Chargaff's Rule.
  2. This means the amount of Adenine (A) is equal to the amount of Thymine (T), and the amount of Guanine (G) is equal to the amount of Cytosine (C).
  3. Given that Adenine (A) makes up \(30 \%\) of the DNA, the percentage of Thymine (T) must also be \(30 \%\).
  4. Since the total percentage of all the bases must equal \(100 \%\), the remaining percentage for Guanine (G) and Cytosine (C) combined is \(100 \% - (30 \% + 30 \%) = 40 \%.\)
  5. Assuming the DNA is double-stranded and the percentages of G and C are equal, the percentage for Guanine (G) is \(20 \%\), and for Cytosine (C) is also \(20 \%.\)

Therefore, the percentage composition of Thymine, Guanine, and Cytosine in the DNA is:

  • Thymine (T): \(30 \%\)
  • Guanine (G): \(20 \%\)
  • Cytosine (C): \(20 \%\)

The correct answer is \(T : 30 ; G : 20 ; C : 20\).

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Concepts Used:

Structure of DNA and RNA

DNA Structure:

Human DNA is unique and is made up of 3 billion base pairs. However, 99% of them are the same in all humans. The sequence of these bases determines what information needs to be coded that is necessary for the organism's growth and development. During the process of transcription (when DNA is replicated), a product is formed known as RNA (Ribonucleic Acid). This RNA is responsible for translating genetic information from DNA to protein followed by reading through ribosomes. 

Read More: Structure of DNA

RNA Structure:

The ribonucleic acid has all the components same to that of the DNA with only 2 main differences within it. RNA has the same nitrogen bases called the adenine, Guanine, Cytosine as that of the DNA except for the Thymine which is replaced by the uracil. Adenine and uracil are considered as the major building blocks of RNA and both of them form base-pair with the help of 2 hydrogen bonds.

RNA resembles a hairpin structure and like the nucleotides in DNA, nucleotides are formed in this ribonucleic material(RNA). Nucleosides are nothing but the phosphate groups which sometimes also helps in the production of nucleotides in the DNA.

Read More: Structure of RNA