Question

How does it differ from triple-negative essential thrombocytosis in prognosis?

Hint:

TN-MF has a worse prognosis than TN-ET due to its aggressive nature, including the risk of progression to AML and overall shorter survival.

Answer 1

Step 1: Triple-Negative Essential Thrombocytosis (TN-ET).
Triple-negative essential thrombocytosis (TN-ET) is another form of myeloproliferative neoplasm characterized by elevated platelet counts and the absence of JAK2, CALR, or MPL mutations. In contrast to TN-MF, TN-ET has a better prognosis and is typically associated with fewer complications, such as thrombosis and hemorrhage.

Step 2: Prognosis Comparison.
1. TN-MF Prognosis: TN-MF is more aggressive and is associated with a higher risk of progression to acute myeloid leukemia (AML) and worse overall survival. The prognosis is typically poor, especially in elderly patients.
2. TN-ET Prognosis: TN-ET generally has a better prognosis, with a risk of thrombosis being the most common complication. It has a much lower risk of progression to leukemia or myelofibrosis compared to TN-MF. Treatment primarily focuses on controlling the platelet count to reduce thrombotic risks.

Step 3: Key Differences.
- TN-MF is characterized by bone marrow fibrosis and a poor prognosis, while TN-ET is associated with elevated platelets and a more indolent course. - TN-MF is more likely to transform into AML, while TN-ET rarely progresses to more aggressive forms of leukemia.