Step 1: Rule of prepositions with time expressions.
- “Since” is used with a specific point in time (e.g., since 2005, since yesterday).
- “For” is used with a duration of time (e.g., for two years, for a long time).
Step 2: Apply to the sentence.
The phrase “a long time” is a duration, so the correct preposition is “for,” not “since.”
Step 3: Correction.
The correct sentence should be:
“He knows Ramu for a long time.”
Step 4: Conclusion.
The incorrect word in the sentence is “since.”
Final Answer:
\[
\boxed{\text{since}}
\]