Question

H/o recurrent abortions at 8,11& 22 weeks. Cardiac activity is normal in all the three. H/o of preeclampsia in last pregnancy. What is the most probable cause

• A. Syphilis
• B. APLA
• C. TORCH
• D. GDM

Answer 1

The Correct Option is A

The case describes a patient with a history of recurrent abortions occurring at 8, 11, and 22 weeks, with normal fetal cardiac activity in all instances. Additionally, the patient has a history of preeclampsia in her last pregnancy.

To determine the most probable cause, we should consider common causes of recurrent pregnancy loss and related complications:

1. Antiphospholipid Antibody Syndrome (APLA): Known for causing recurrent miscarriages, typically unexplained embryo demise, thrombosis, and fetal growth restriction.
2. Syphilis: One of the potential causes of recurrent miscarriage and may result in fetal death, often with a pattern of loss similar to this case.
3. TORCH infections: Typically associated with teratogenic effects rather than recurrent loss alone.
4. Gestational Diabetes Mellitus (GDM): Generally linked to complications later in pregnancy, not recurrent early pregnancy losses.

Given the provided options, syphilis stands out as a cause of recurrent abortion at different stages of pregnancy (8, 11, and 22 weeks), which fits the patient's history, including normal fetal cardiac activity prior to loss and preeclampsia.

Therefore, the most probable cause of the recurrent abortions in this scenario is Syphilis.