"Efficacious'' means effective; producing the desired result.
Step 1: Analyze options
- (A) Ineffective: not producing any significant or desired effect.
- (B) Ugly: unpleasant to look at.
- (C) Careless: not giving sufficient attention or thought.
- (D) Uncooperative: unwilling to work with others.
Step 2: Find opposite
The opposite of "Efficacious'' (effective) is "Ineffective'' (not effective), so option (A) is correct.