We begin by applying substitution. Define: \[ u = x^4 + 1 \] which gives: \[ du = 4x^3 \, dx \] Next, we rewrite the given integral in terms of \( u \).
Noticing the presence of \( x^2 \) and \( x^3 \) in the integral, we express \( x^2 \) as \( x^3 \cdot x^{-1} \), transforming the integral into: \[ \int \frac{dx}{x^2 (x^4 + 1)^{3/4}} = \int \frac{du}{x^2 u^{3/4}} \] Upon further simplification and solving, we obtain: \[ \int \frac{dx}{x^2 (x^4 + 1)^{3/4}} = -\frac{(x^4 + 1)^{1/4}}{x^4} + C \]
Thus, the correct answer is \( -\frac{(x^4 + 1)^{1/4}}{x^4} + C \).