Question

Ethylketazocine is a 6,7‐benzomorphan derivative with _____ receptor selectivity.

• A. Mu–opioid
• B. Delta–opioid
• C. Kappa–opioid
• D. NOP

Answer 1

The Correct Option is C

To determine the receptor selectivity of Ethylketazocine, we need to consider the pharmacological properties and class of this compound.

Ethylketazocine is a derivative of the 6,7-benzomorphan class, which is known for its action on opioid receptors. Opioid receptors are classified into several types, mainly: mu (μ), delta (δ), kappa (κ), and NOP (nociceptin/orphanin FQ peptide receptor). Each receptor subtype has distinct physiological roles and different affinities for various opioid compounds.

Ethylketazocine specifically is known to have a high affinity for the kappa-opioid receptor. The kappa-opioid receptor is one of the primary targets for this compound and mediates different effects compared to mu and delta receptors, such as dysphoria and diuresis, in contrast to the euphoric effects often associated with mu-opioid receptor activation.

Therefore, the correct receptor selectivity for Ethylketazocine is the kappa-opioid receptor. Let's evaluate the options:

• Mu–opioid: Not the correct choice as Ethylketazocine does not primarily target this receptor.
• Delta–opioid: Although delta receptors are part of the opioid receptor family, Ethylketazocine does not have selectivity for this receptor.
• Kappa–opioid: This is the correct choice as Ethylketazocine is known for its selectivity towards the kappa-opioid receptor.
• NOP: This receptor is not known to be the primary target of Ethylketazocine.

Hence, the correct answer is the Kappa–opioid receptor selectivity.