Question

Enzyme commonly targeted by drugs to treat hypertension is:

• A. Cyclooxygenase (COX)
• B. HMG-CoA reductase
• C. Angiotensin-converting enzyme (ACE)
• D. Monoamine oxidase (MAO)

Hint:

ACE inhibitors are among the most effective drugs for managing hypertension by targeting the renin-angiotensin-aldosterone system (RAAS).

Answer 1

The Correct Option is C

Step 1: Understanding the role of ACE in hypertension. The angiotensin-converting enzyme (ACE) plays a key role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure. ACE converts angiotensin I into angiotensin II, a potent vasoconstrictor that increases blood pressure by narrowing blood vessels. Step 2: Mechanism of ACE inhibitors. ACE inhibitors, such as enalapril and captopril, are commonly used to treat hypertension. They block the activity of ACE, reducing the production of angiotensin II, which leads to: - Vasodilation (widening of blood vessels), - Lowered blood pressure, and - Reduced strain on the heart. Step 3: Why other options are incorrect. - Cyclooxygenase (COX): Targeted by NSAIDs to reduce inflammation and pain, not for hypertension. - HMG-CoA reductase: Targeted by statins to lower cholesterol levels. - Monoamine oxidase (MAO): Targeted in the treatment of depression, not directly related to hypertension.