Question:

During DNA replication, Okazaki fragments are used to elongate:

Updated On: Aug 20, 2024
  • The lagging strand towards replication fork
  • The leading strand away from replication fork
  • The lagging strand away from the replication fork
  • The leading strand towards replication fork
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The Correct Option is C

Solution and Explanation

Two DNA polymerase molecules work simultaneous at the DNA fork, one on the leading strand and the other on the lagging strand.
Each Okazaki fragment is synthesized by DNA polymerase at lagging strand in $5'\rightarrow 3'$ direction. New Okazaki fragments appear as the replication fork opens further.
As the first Okazaki fragment appears away from the replication fork, the direction of elongation would be away from replication fork.
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Concepts Used:

The Molecular Basis of Inheritance

DNA Replication:

DNA synthesis is commenced at particular points within the DNA strand referred to as ‘origins’, which are certain coding regions. There are numerous origin sites, and when replication of DNA starts, these sites are mentioned as replication forks. Within the replication, the complex is the enzyme DNA Helicase, so that they can be utilized as a template for replication. DNA Primase is another enzyme that's essential in DNA replication.

RNA:

Ribonucleic acid (RNA) is an essential biological macromolecule that exists all together in biological cells. It is principally involved in the synthesis of proteins, that carry the messenger instructions from DNA, which itself contains the genetic instructions needed for the event and maintenance of life. In some viruses, RNA, in spite of DNA, carries genetic information.

Genetic Code:

Genetic code is the term we use in the manner that the four bases of DNA--the A, C, G, and Ts--are strung together in a way that the ribosome, the cellular machinery, can read them and switch them into a protein. In the ordering, every three nucleotides during a row count as a triplet and code for one amino alkanoic acid.

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