Question

Drug of choice for resistant rheumatic chorea?

• A. Valproate
• B. Haloperidol
• C. Diazepam
• D. Probenecid

Answer 1

The Correct Option is A

In the management of resistant rheumatic chorea, various pharmacological options can be considered. Rheumatic chorea, a component of rheumatic fever, is a movement disorder characterized by rapid, jerky movements. When the condition is resistant to standard treatment approaches, we need to consider medications that have anticonvulsant and mood-stabilizing properties.

The recommended drug of choice in such resistant cases is Valproate. Valproate, also known as valproic acid, is an anticonvulsant and mood stabilizer that works by increasing the amount of gamma-aminobutyric acid (GABA) in the brain, which helps to reduce neuronal excitability and stabilize mood.

Option	Explanation
Valproate	The preferred choice for resistant rheumatic chorea due to its effectiveness in controlling involuntary movements and mood stabilization.
Haloperidol	An antipsychotic with potential use in movement disorders but less preferred due to side effects like tardive dyskinesia.
Diazepam	A benzodiazepine used for anxiety and muscle spasms, not typically effective for rheumatic chorea.
Probenecid	A medication used to increase uric acid excretion; not applicable for chorea management.

In conclusion, Valproate stands out as the most effective treatment for patients with resistant rheumatic chorea, allowing for better control over involuntary movements.