Question

DOC for chemotherapy induced vomiting is?

• A. Graneseteron
• B. Prazosin
• C. Clonidine
• D. Dimenhydrinate

Answer 1

The Correct Option is A

To determine the DOC (Drug of Choice) for chemotherapy-induced vomiting, we need to consider the primary mechanism and receptors involved in this condition. Chemotherapy often triggers nausea and vomiting by releasing serotonin (5-HT) in the gut, which then binds to 5-HT3 receptors, leading to the emetic reflex. Therefore, drugs that block these 5-HT3 receptors are effective in preventing and treating this kind of nausea and vomiting.

Among the given options:

• Graneseteron: A selective 5-HT3 receptor antagonist used specifically to prevent chemotherapy-induced nausea and vomiting.
• Prazosin: An alpha-1 adrenergic receptor blocker, primarily used for hypertension, not effective for chemotherapy-induced vomiting.
• Clonidine: An alpha-2 adrenergic agonist, used for hypertension and certain withdrawal symptoms, not indicated for chemotherapy-induced vomiting.
• Dimenhydrinate: An antihistamine used to treat motion sickness, not specifically effective against chemotherapy-induced vomiting.

Based on the pharmacological profile and effectiveness:

Correct Answer: Graneseteron