Question

Discuss the common antibodies found in JDM and their clinical associations.

Hint:

Anti-Mi-2 and anti-Jo-1 antibodies are critical in diagnosing JDM and help to assess the prognosis and disease severity.

Answer 1

Step 1: Common Antibodies in JDM.
Several autoantibodies are commonly found in JDM, including anti-Mi-2 antibodies, which are most specific for dermatomyositis, and anti-Jo-1 antibodies, which are also seen in patients with polymyositis and are associated with interstitial lung disease.
Step 2: Clinical Associations.
- Anti-Mi-2 antibodies: These are strongly associated with classic dermatomyositis and are linked to a better prognosis.
- Anti-Jo-1 antibodies: These are associated with a more severe form of the disease, including lung involvement and fibrosis.