Define the following as related to proteins (i)Peptide linkage (ii)Primary structure (iii)Denaturation.
Solution and Explanation
(i) Peptide linkage:
The amide formed between -COOH group of one molecule of an amino acid and -NH2group of another molecule of the amino acid by the elimination of a water molecule is called a peptide linkage.
(ii) Primary structure:
The primary structure of protein refers to the specific sequence in which various amino acids are present in it, i.e., the sequence of linkages between amino acids in a polypeptide chain. The sequence in which amino acids are arranged is different in each protein. A change in the sequence creates a different protein.
(iii) Denaturation:
In a biological system, a protein is found to have a unique 3-dimensional structure and a unique biological activity. In such a situation, the protein is called native protein. However, when the native protein is subjected to physical changes such as change in temperature or chemical changes such as change in pH, its H-bonds are disturbed. This disturbance unfolds the globules and uncoils the helix. As a result, the protein loses its biological activity. This loss of biological activity by the protein is called denaturation. During denaturation, the secondary and the tertiary structures of the protein get destroyed, but the primary structure remains unaltered.
One of the examples of denaturation of proteins is the coagulation of egg white when an egg is boiled.
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Concepts Used:
Proteins
An essential part of every cell in our body, protein is one of the three macronutrients which is required by our body in larger amounts. Proteins are made up of linear chains of smaller units called amino acids. Every biochemical process that takes place inside our bodies is possible because of these proteins. Proteins are 3-dimensional structures that are assembled with different amino acid sequences.
Functions of Protein
Proteins are used in many ways. Some of their functions are:
- Enzymes: Most of the important chemical reactions which take place inside a cell are mostly carried out by enzymes. They also play a role in regenerating and creating DNA molecules and carrying out complex processes.
- Hormonal Regulation: Proteins create various types of hormones that help in balancing the components of the body. For example, hormones like insulin help in regulating blood sugar and secretin. The formation of digestive juices essential for the whole digestion process is also possible because of hormones.
- Protection: Being the main constituent of antibodies, proteins protect our body against antigens and pathogens thus preventing infections.
- Energy: Proteins are one the most essential sources of energy required for our body movements. The right amount of proteins should be consumed so that they can be turned into energy.
- Structural functions: Proteins are the building blocks of the body. They are required for the growth, development, healing, and repair of tissues. Proteins are essential in order to strengthen various structures like hair, skin, and muscles. It is also present in the outer membrane of all cells in the human body.
Classification of Protein
Proteins are classified on the basis of:
- Shape
- Constitution
- Nature of Molecules
Protein Structure
A protein molecule is made from a long chain of amino acids, each linked to its neighbor through a covalent peptide bond. The structure of proteins are divided into four types:
- Primary Structure
- Secondary Structure
- Tertiary Sector
- Quaternary Structure