Question

De novo synthesis of purines, is not operative in
(A) Liver
(B) Erythrocytes
(C) Kidney
(D) Brain
Choose the correct answer from the options given below:

• A. (B) and (D) only.
• B. (A) and (C) only.
• C. (A), and (B) only
• D. (C) and (D) only.

Hint:

De novo purine synthesis is essential in many tissues except in erythrocytes and the brain where alternative pathways are utilized

Answer 1

The Correct Option is B

The de novo synthesis of purines does not occur in erythrocytes and brain Erythrocytes lack the necessary organelles for de novo purine synthesis while the brain relies on the salvage pathway for purines The liver and kidneys are involved in the de novo synthesis of purines