Question

Corneal Transparency is maintained by which of the following GAGs

• A. Keratan Sulphate
• B. Dermatan Sulphate
• C. Heparan Sulphate
• D. Chondroitin Sulphate

Answer 1

The Correct Option is A

To determine which glycosaminoglycan (GAG) is responsible for maintaining corneal transparency, we need to understand the role of different GAGs in the corneal structure. The cornea must remain transparent to allow light to enter the eye properly. This transparency is largely maintained by a balance of hydration and the organization of collagen fibrils, in which GAGs play a crucial role.

Among the options:

• Keratan Sulphate: Primarily located in the cornea, it contributes significantly to maintaining corneal transparency by regulating hydration and spacing of collagen fibrils.
• Dermatan Sulphate: Predominantly found in the skin and connective tissue, not primarily associated with the cornea.
• Heparan Sulphate: Found in various tissues, its role is more about cell adhesion and proliferation rather than cornea transparency.
• Chondroitin Sulphate: Often found in cartilage, it is not specific to corneal transparency.

The correct answer is Keratan Sulphate, as it is the GAG specifically involved in maintaining corneal transparency by effectively managing the corneal matrix's hydration and spatial structure.