Question

Cooley’s Anaemia is controlled by single gene present on

• A. Chromosome – 1
• B. Chromosome – 16
• C. Chromosome – 9
• D. Chromosome – 11

Hint:

Remember: The HBB gene responsible for Beta-Thalassemia is located on chromosome 11.

Answer 1

The Correct Option is D

Cooley's Anaemia, also known as Beta-Thalassemia, is a genetic blood disorder that affects hemoglobin production. It is caused by mutations in the HBB gene, which is located on chromosome 11.
This gene encodes the beta-globin subunit of hemoglobin, and mutations lead to reduced or absent beta-globin chains, resulting in abnormal hemoglobin formation and severe anemia.
- Options (1), (2), and (3) are incorrect because they do not carry the HBB gene.
Therefore, Cooley’s Anaemia is controlled by a gene present on chromosome 11.

Answer 2

Cooley’s Anaemia, also known as beta-thalassemia, is a genetic blood disorder characterized by reduced production of hemoglobin beta chains. This condition leads to anemia due to ineffective red blood cell formation and increased destruction.

The gene responsible for beta-thalassemia is the HBB gene, which codes for the beta-globin subunit of hemoglobin. This gene is located on the short arm of chromosome 11 (specifically at 11p15.5). Mutations in this gene result in decreased or absent beta-globin chain production.

Because Cooley’s Anaemia is caused by mutations in a single gene on chromosome 11, it follows a Mendelian inheritance pattern, typically autosomal recessive.

Therefore, Cooley’s Anaemia is controlled by a single gene present on chromosome 11.