To find the minimum value of \( f(x) = -x^2 + 10x + 100 \) in the interval \( [5, 10] \), we first compute the derivative:
\[
f'(x) = -2x + 10
\]
Setting \( f'(x) = 0 \) to find the critical points:
\[
-2x + 10 = 0 $\Rightarrow$ x = 5
\]
Now, we evaluate \( f(x) \) at the endpoints \( x = 5 \) and \( x = 10 \):
\[
f(5) = -(5)^2 + 10(5) + 100 = -25 + 50 + 100 = 125
\]
\[
f(10) = -(10)^2 + 10(10) + 100 = -100 + 100 + 100 = 100
\]
Thus, the minimum value is \( 100 \).