Question

Consider the following statements:
Assertion (A): During blood clotting, at one stage, soluble fibrin is formed
Reason (R): Factor XIII, released from platelets, converts it into insoluble fibrin fibres. Factor XIII replaces the hydrogen bonds present among the monomers of soluble fibrin with covalent bonds

• A. Both (A) and (R) are true, (R) is the correct explanation of (A)
• B. Both (A) and (R) are true, (R) is not the correct explanation of (A)
• C. (A) is true, but (R) is false
• D. (A) is false, but (R) is true

Hint:

Factor XIII is crucial for the final stabilization of fibrin during coagulation. Soluble fibrin is unstable until cross-linked. Always link the factor to its specific enzymatic function.

Answer 1

The Correct Option is A

Soluble fibrin is formed initially; Factor XIII (fibrin stabilizing factor) cross-links the fibrin monomers to form insoluble fibrin fibers, stabilizing the clot. Both Assertion and Reason are correct.