Question:
Child presents with sunlight causing eruptions, diagnosed with a DNA repair defect. Which defect could it be?
Child presents with sunlight causing eruptions, diagnosed with a DNA repair defect. Which defect could it be?
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Nucleotide excision repair (NER) defects are associated with diseases such as xeroderma pigmentosum, where the body cannot repair UV-induced DNA damage.
Updated On: Mar 24, 2025
- Nucleotide excision
- Base excision repair
- Mismatch repair defect
- Recombination defect
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The Correct Option is A
Solution and Explanation
The presentation of sunlight-induced eruptions suggests a defect in the DNA repair mechanism, specifically in the nucleotide excision repair (NER) pathway. This pathway is responsible for repairing UV-induced DNA damage, and defects in NER lead to conditions like xeroderma pigmentosum, which causes extreme sensitivity to sunlight.
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