Question

Chemotherapy agents for retinoblastoma:

• A. vincristine ,carboplatin and etoposide
• B. vinblastine, etoposide and bleomycin
• C. vinblastine , vincristine and etoposide
• D. vinblastine , vincristine and cisplatin

Answer 1

The Correct Option is A

In the treatment of retinoblastoma, a rare pediatric retinal cancer, chemotherapy plays a vital role. The agents commonly used in chemotherapy for retinoblastoma are chosen for their effectiveness in penetrating the blood-retinal barrier and targeting cancer cells while minimizing toxicity.

The chemotherapy regimen for retinoblastoma typically includes a combination of three drugs:

• Vincristine
• Carboplatin
• Etoposide

This combination is chosen over others due to its proven efficacy in clinical studies and outcomes observed in patients. Let's explore these drugs:

• Vincristine: A vinca alkaloid that works by inhibiting microtubule formation in the mitotic spindle, effectively stopping cancer cell division.
• Carboplatin: A platinum-based chemotherapeutic agent that causes DNA crosslinking, leading to apoptosis of cancer cells.
• Etoposide: A podophyllotoxin derivative that inhibits DNA topoisomerase II, preventing DNA replication and leading to cell death.

By combining these drugs, the treatment aims to maximize cancer cell kill rates while minimizing the emergence of resistance and adverse effects. Therefore, the correct combination for chemotherapy in retinoblastoma is vincristine, carboplatin, and etoposide.