Certain variants of key behavioural genes, “risk allele” make people more vulnerable to certain mood, psychiatric, or personality disorders. An allele is any of the variants of a gene that takes more than one form. A risk allele, then, is simply a gene variant that increases your likelihood of developing a problem.
Researchers have identified a dozen-odd gene variants that can increase a person’s susceptibility to depression, anxiety and antisocial, sociopathic, or violent behaviours, and other problems — if, and only if, the person carrying the variant suffers a traumatic or stressful childhood or faces particularly trying experiences later in life. This hypothesis, often called the “stress diathesis” or “genetic vulnerability” model, has come to saturate psychiatry and behavioural science.
Recently, however, an alternate hypothesis has emerged from this one and is turning it inside out. This new model suggests that it’s a mistake to understand these “risk” genes only as liabilities. According to this new thinking, these “bad genes” can create dysfunctions in unfavourable contexts — but they can also enhance function in favourable contexts. The genetic sensitivities to negative experience that the vulnerability hypothesis has identified, it follows, are just the downside of a bigger phenomenon: a heightened genetic sensitivity to all experience.
This hypothesis has been anticipated by Swedish folk wisdom which has long spoken of “dandelion” children. These dandelion children — equivalent to our “normal” or “healthy” children, with “resilient” genes — do pretty well almost anywhere, whether raised in the equivalent of a sidewalk crack or well-tended garden. There are also “orchid” children, who will wilt if ignored or maltreated but bloom spectacularly with greenhouse care. According to this orchid hypothesis, risk becomes possibility; vulnerability becomes plasticity and responsiveness. Gene variants generally considered misfortunes can instead now be understood as highly leveraged evolutionary bets, with both high risks and high potential rewards.
In this view, having both dandelion and orchid kids greatly raises a family’s (and a species’) chance of succeeding, over time and in any given environment. The behavioural diversity provided by these two different types of temperament also supplies precisely what a smart, strong species needs if it is to spread across and dominate a changing world. The many dandelions in a population provide an underlying stability. The less-numerous orchids, meanwhile, may falter in some environments but can excel in those that suit them. And even when they lead troubled early lives, some of the resulting heightened responses to adversity that can be problematic in everyday life — increased novelty-seeking, restlessness of attention, elevated risk-taking, or aggression — can prove advantageous in certain challenging situations: wars, social strife of many kinds, and migrations to new environments. Together, the steady dandelions and the mercurial orchids offer an adaptive flexibility that neither can provide alone. Together, they open a path to otherwise unreachable individual and collective achievements.


When people who are talking don’t share the same culture, knowledge, values, and assumptions, mutual understanding can be especially difficult. Such understanding is possible through the negotiation of meaning. To negotiate meaning with someone, you have to become aware of and respect both the differences in your backgrounds and when these differences are important. You need enough diversity of cultural and personal experience to be aware that divergent world views exist and what they might be like. You also need the flexibility in world view, and a generous tolerance for mistakes, as well as a talent for finding the right metaphor to communicate the relevant parts of unshared experiences or to highlight the shared experiences while demphasizing the others. Metaphorical imagination is a crucial skill in creating rapport and in communicating the nature of unshared experience. This skill consists, in large measure, of the ability to bend your world view and adjust the way you categorize your experiences. Problems of mutual understanding are not exotic; they arise in all extended conversations where understanding is important.
When it really counts, meaning is almost never communicated according to the CONDUIT metaphor, that is, where one person transmits a fixed, clear proposition to another by means of expressions in a common language, where both parties have all the relevant common knowledge, assumptions, values, etc. When the chips are down, meaning is negotiated: you slowly figure out what you have in common, what it is safe to talk about, how you can communicate unshared experience or create a shared vision. With enough flexibility in bending your world view and with luck and charity, you may achieve some mutual understanding.
Communication theories based on the CONDUIT metaphor turn from the pathetic to the evil when they are applied indiscriminately on a large scale, say, in government surveillance or computerized files. There, what is most crucial for real understanding is almost never included, and it is assumed that the words in the file have meaning in themselves—disembodied, objective, understandable meaning. When a society lives by the CONDUITmetaphor on a large scale, misunderstanding, persecution, and much worse are the likely products.
Later, I realized that reviewing the history of nuclear physics served another purpose as well: It gave the lie to the naive belief that the physicists could have come together when nuclear fission was discovered (in Nazi Germany!) and agreed to keep the discovery a secret, thereby sparing humanity such a burden. No. Given the development of nuclear physics up to 1938, development that physicists throughout the world pursued in all innocence of any intention of finding the engine of a new weapon of mass destruction—only one of them, the remarkable Hungarian physicist Leo Szilard, took that possibility seriously—the discovery of nuclear fission was inevitable. To stop it, you would have had to stop physics. If German scientists hadn’t made the discovery when they did, French, American, Russian, Italian, or Danish scientists would have done so, almost certainly within days or weeks. They were all working at the same cutting edge, trying to understand the strange results of a simple experiment bombarding uranium with neutrons. Here was no Faustian bargain, as movie directors and other naifs still find it intellectually challenging to imagine. Here was no evil machinery that the noble scientists might hide from the problems and the generals. To the contrary, there was a high insight into how the world works, an energetic reaction, older than the earth, that science had finally devised the instruments and arrangements to coart forth. “Make it seem inevitable,” Louis Pasteur used to advise his students when they prepared to write up their discoveries. But it was. To wish that it might have been ignored or suppressed is barbarous. “Knowledge,” Niels Bohr once noted, “is itself the basis for civilization.” You cannot have the one without the other; the one depends upon the other. Nor can you have only benevolent knowledge; the scientific method doesn’t filter for benevolence. Knowledge has consequences, not always intended, not always comfortable, but always welcome. The earth revolves around the sun, not the sun around the earth. “It is a profound and necessary truth,” Robert Oppenheimer would say, “that the deep things in science are not found because they are useful; they are found because it was possible to find them.”
...Bohr proposed once that the goal of science is not universal truth. Rather, he argued, the modest but relentless goal of science is “the gradual removal of prejudices.” The discovery that the earth revolves around the sun has gradually removed the prejudice that the earth is the center of the universe. The discovery of microbes is gradually removing the prejudice that disease is a punishment from God. The discovery of evolution is gradually removing the prejudice that Homo sapiens is a separate and special creation.
Light Chemicals is an industrial paint supplier with presence in three locations: Mumbai, Hyderabad and Bengaluru. The sunburst chart below shows the distribution of the number of employees of different departments of Light Chemicals. There are four departments: Finance, IT, HR and Sales. The employees are deployed in four ranks: junior, mid, senior and executive. The chart shows four levels: location, department, rank and gender (M: male, F: female). At every level, the number of employees at a location/department/rank/gender are proportional to the corresponding area of the region represented in the chart.
Due to some issues with the software, the data on junior female employees have gone missing. Notice that there are junior female employees in Mumbai HR, Sales and IT departments, Hyderabad HR department, and Bengaluru IT and Finance departments. The corresponding missing numbers are marked u, v, w, x, y and z in the diagram, respectively.
It is also known that:
a) Light Chemicals has a total of 210 junior employees.
b) Light Chemicals has a total of 146 employees in the IT department.
c) Light Chemicals has a total of 777 employees in the Hyderabad office.
d) In the Mumbai office, the number of female employees is 55.

An investment company, Win Lose, recruit's employees to trade in the share market. For newcomers, they have a one-year probation period. During this period, the employees are given Rs. 1 lakh per month to invest the way they see fit. They are evaluated at the end of every month, using the following criteria:
1. If the total loss in any span of three consecutive months exceeds Rs. 20,000, their services are terminated at the end of that 3-month period,
2. If the total loss in any span of six consecutive months exceeds Rs. 10,000, their services are terminated at the end of that 6-month period.
Further, at the end of the 12-month probation period, if there are losses on their overall investment, their services are terminated.
Ratan, Shri, Tamal and Upanshu started working for Win Lose in January. Ratan was terminated after 4 months, Shri was terminated after 7 months, Tamal was terminated after 10 months, while Upanshu was not terminated even after 12 months. The table below, partially, lists their monthly profits (in Rs. ‘000’) over the 12-month period, where x, y and z are masked information.
Note:
• A negative profit value indicates a loss.
• The value in any cell is an integer.
Illustration: As Upanshu is continuing after March, that means his total profit during January-March (2z +2z +0) ≥
Rs.20,000. Similarly, as he is continuing after June, his total profit during January − June ≥
Rs.10,000, as well as his total profit during April-June ≥ Rs.10,000.