Question

Blood stored in citrate-phosphate-dextrose is better for hypoxic patients than acidic-citrate-dextrose because?

• A. It has less P₅₀
• B. It is less acidic
• C. The fall in 2, 3 DPG is less
• D. None of the above

Answer 1

The Correct Option is C

Blood stored in citrate-phosphate-dextrose (CPD) is preferable for hypoxic patients over acidic-citrate-dextrose (ACD) primarily due to the different impacts these solutions have on 2,3-Diphosphoglycerate (2,3-DPG) levels. 2,3-DPG is a critical molecule that influences the oxygen affinity of hemoglobin. Its presence decreases the affinity, thereby facilitating oxygen release to the tissues, which is paramount in hypoxic conditions.

Here's why the fall in 2,3-DPG matters:

• 2,3-DPG Role: 2,3-DPG binds to hemoglobin and reduces its oxygen affinity, enabling greater oxygen delivery to peripheral tissues.
• Storage Impact: During blood storage, the levels of 2,3-DPG decline, which can result in increased oxygen affinity and reduced delivery to tissues.
• CPD vs. ACD: Studies have shown that blood stored in CPD experiences a slower decline in 2,3-DPG levels compared to ACD, which is beneficial in maintaining appropriate oxygen delivery, especially for hypoxic patients.

Thus, the key reason CPD is better than ACD for hypoxic patients is that the fall in 2,3-DPG is less, ensuring continued efficient oxygen delivery. This makes the choice crucial in clinical situations where maximizing tissue oxygenation is vital.