Question

Antegrade peristalsis due to? 

• A. Ach
• B. Serotonin
• C. Substance P
• D. VIP

Answer 1

The Correct Option is D

Antegrade peristalsis, the forward-moving contraction of the gastrointestinal tract, is influenced by several neurotransmitters. Specifically, Vasoactive Intestinal Peptide (VIP) plays a critical role in this process.

The options include:

• Ach (Acetylcholine): A neurotransmitter that generally stimulates muscle contractions but is not primarily responsible for antegrade peristalsis.
• Serotonin: Known for its role in mood regulation but it also influences gut motility. However, it's more significant in regulating intestinal movements, not specifically linked to promoting antegrade peristalsis.
• Substance P: An important neurotransmitter associated with inflammation and pain perception. Its role in gut motility is less direct compared to VIP.
• VIP (Vasoactive Intestinal Peptide): VIP facilitates smooth muscle relaxation in the gastrointestinal tract, promoting antegrade peristalsis by initiating a wave-like motion that pushes contents forward.

Therefore, the correct answer is VIP.