Question

Androgen replacement therapy.

Hint:

Close monitoring of testosterone levels and side effects is essential during androgen replacement therapy to ensure safety and efficacy.

Answer 1

Androgen replacement therapy aims to restore normal testosterone levels and alleviate the symptoms of androgen deficiency.
Step 1: Routes of Administration:
1. Intramuscular Injections: Testosterone enanthate or cypionate are commonly used for injections, given every 1-2 weeks.
2. Transdermal Patches or Gels: Testosterone is applied daily to the skin, providing more consistent testosterone levels.
3. Pellets: Testosterone pellets are implanted subcutaneously and release testosterone over several months.
Step 2: Monitoring During Therapy:
- Monitor testosterone levels after starting therapy to ensure they reach the normal range (300-1000 ng/dL).
- Regular follow-up includes checking for side effects such as elevated hematocrit, prostate abnormalities, and cardiovascular symptoms.
Step 3: Adjustments and Side Effects:
- Adjust dosage based on clinical response and side effects. Common side effects include acne, gynecomastia, and mood changes.
- Ensure that there is no excessive increase in hematocrit levels, which could increase the risk of blood clots.