Question

Aldosterone synthesis is stimulated by which of the following ?

• A. ACTH
• B. Hyperkalemia
• C. Hypernatremia
• D. Exogenous steroids

Answer 1

The Correct Option is B

Aldosterone is a hormone produced by the adrenal glands, which plays a crucial role in regulating blood pressure by controlling sodium and potassium levels in the blood. The synthesis of aldosterone is primarily stimulated by three major factors:

1. Renin-Angiotensin System: Activation of this system due to decreased blood pressure or sodium concentrations leads to the production of angiotensin II, a potent stimulator of aldosterone synthesis.
2. Hyperkalemia: Elevated levels of potassium in the blood directly stimulate the adrenal cortex to produce more aldosterone, which helps increase the excretion of potassium from the body, thereby reducing hyperkalemia.
3. Adrenocorticotropic Hormone (ACTH): Though ACTH can stimulate adrenal function, it is not a primary regulator of aldosterone synthesis compared to the factors mentioned above.

Based on the given options, Hyperkalemia is the correct answer. It is a direct and significant stimulator of aldosterone synthesis, helping to maintain electrolyte balance and normal blood pressure levels by promoting potassium excretion and sodium retention.