The clinical presentation of fever, sore throat, malaise, abdominal pain, conjunctival suffusion, and calf tenderness, without a history of cough, vomiting, hemorrhage, and travel, is most consistent with Leptospirosis. This zoonotic disease is caused by the Leptospira bacteria, which are typically transmitted through contact with water or soil contaminated by the urine of infected animals. Chikungunya and Dengue hemorrhagic fever present with different clinical features, and hepatic encephalopathy with hepatitis A typically presents with jaundice and altered mental status.