Question

A tablet excipient, whose function to ensure that table formulation and ejection can occur with low friction between the solid and the die wall is called:

• A. Glidant
• B. Lubricant
• C. Anti-adhesive
• D. Binder

Answer 1

The Correct Option is B

In tablet formulation, the role of various excipients is crucial to ensure that the tablets have the desired properties for effectiveness and manufacturability. The term "excipient" refers to inactive substances that serve various functions in the formulation of tablets. The question is about an excipient that minimizes friction between the solid tablet and the die wall during the tableting process, allowing smooth ejection of the tablet.

The correct answer is Lubricant. Let's explore why this is the right choice and rule out the other options:

1. Glidant: Glidants are added to improve the flow properties of the powder mixture. They help in reducing friction between particles during mixing and compaction, which improves the flowability of the powder. However, they are not specifically aimed at reducing friction during ejection from the die walls.
2. Lubricant: This is the correct answer. The primary function of lubricants in tablet formulation is to ensure that the ejection of tablets from the die is smooth and occurs with minimal friction. Lubricants form a boundary layer between the tablet and die wall, which reduces the friction and prevents sticking or capping of tablets during ejection.
3. Anti-adhesive: Anti-adhesives prevent sticking of tablet ingredients to the punches and dies during compression. While they help in reducing sticking, their primary function is not to reduce friction during ejection. They prevent adhesion, which could lead to defects on the tablet surface.
4. Binder: Binders are used to hold the ingredients of a tablet together by providing cohesion. They ensure the tablet remains intact after compression. Binders are not primarily responsible for reducing friction during ejection.

In conclusion, the function of reducing friction between the tablet formulation and the die wall during ejection is specifically performed by lubricants. This is why the correct answer is Lubricant. Understanding these roles is critical for ensuring the quality and manufacturability of pharmaceutical products.