A single mutation in a nucleotide base pair resulting in a termination codon is known as a nonsense mutation. In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon, in the transcribed mRNA, and in a truncated, incomplete, and usually nonfunctional protein product. The production of a stop codon prematurely halts protein synthesis. Here's a brief explanation of each option:
- Missense mutation: A point mutation in which a single nucleotide change results in a codon that codes for a different amino acid. This might alter the function of a protein if the change is in an important region.
- Nonsense mutation: Introduces an early stop codon in the genetic sequence, leading to a truncated and usually nonfunctional protein.
- Stop mutation: This term is not typically used in professional literature; it is more accurately described as a nonsense mutation.
- Silent mutation: A change in the nucleotide sequence that does not result in a different amino acid and therefore does not alter the function of the protein.