Step 1: Understanding the condition of trisomy 21. Trisomy of chromosome 21 leads to Down syndrome, a genetic disorder caused by an extra copy of chromosome 21.
Step 2: Symptoms of Down syndrome. Key features include: - Furrowed tongue (i) - Characteristic palm crease (ii) Other traits, such as developmental delays, may also occur.
| List-I | List-II |
| (A) Thalassemia | (I) 47, XXY |
| (B) Klinefelter’s syndrome | (II) Sex-linked recessive disorder |
| (C) Turner’s syndrome | (III) 45, XO |
| (D) Colour blindness | (IV) Autosomal recessive disease |

A ladder of fixed length \( h \) is to be placed along the wall such that it is free to move along the height of the wall.
Based upon the above information, answer the following questions:
(iii) (b) If the foot of the ladder, whose length is 5 m, is being pulled towards the wall such that the rate of decrease of distance \( y \) is \( 2 \, \text{m/s} \), then at what rate is the height on the wall \( x \) increasing when the foot of the ladder is 3 m away from the wall?