Question

A patient presents to the emergency department with a history of ingestion of ten tablets of paracetamol. He has developed oliguria and liver function tests show deranged values. Which of the following can be used in the management of this condition?

• A. N-acetylcysteine
• B. Dopamine
• C. Ursodeoxycholic acid
• D. Furosemide

Answer 1

The Correct Option is A

A patient with a history of paracetamol overdose presents with oliguria and abnormal liver function tests. The management of paracetamol overdose involves the use of N-acetylcysteine. This medication acts as a precursor for glutathione, replenishing its levels and aiding in the detoxification of the toxic metabolites of paracetamol, thereby preventing liver damage. The alternative options listed—Dopamine, Ursodeoxycholic acid, and Furosemide—do not have roles in counteracting the effects of paracetamol toxicity. Dopamine is primarily used for its inotropic effects in cases of shock, Ursodeoxycholic acid is used for certain liver diseases but not for acute overdose management, and Furosemide is a diuretic used for fluid overload, not for detoxification. Proper management requires immediate intervention with N-acetylcysteine to mitigate liver damage.
Correct answer: N-acetylcysteine