Question:
A patient develops mouth ulcers on treatment with Methotrexate. Which of the following will decrease with this drug?
A patient develops mouth ulcers on treatment with Methotrexate. Which of the following will decrease with this drug?
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Methotrexate inhibits folate metabolism, leading to reduced TMP, which is necessary for DNA synthesis, contributing to side effects like mouth ulcers.
Updated On: Mar 24, 2025
- UMP
- TMP
- CMP
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The Correct Option is B
Solution and Explanation
Methotrexate inhibits dihydrofolate reductase, leading to decreased synthesis of tetrahydrofolate. This results in a reduced supply of thymidine monophosphate (TMP), which is essential for DNA synthesis, thereby contributing to side effects like mouth ulcers.
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