Question

A patient comes with a history of asthma and sinusitis. On looking into his medical records, you notice this has been attributed to Samter’s triad. Which drug should be avoided in this patient?

• A. Cotrimoxazole
• B. Co-amoxiclav
• C. Aspirin
• D. Chloramphenicol

Answer 1

The Correct Option is C

The clinical context provided involves a patient with a known history of asthma and sinusitis, attributed to Samter's triad. Samter's triad, also known as aspirin-exacerbated respiratory disease (AERD), consists of asthma, nasal polyps or chronic sinusitis, and sensitivity to aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs).

In the management of patients with Samter's triad, it is critical to avoid drugs that can exacerbate their condition. Aspirin and other NSAIDs are known to potentially trigger respiratory complications in these patients. Given this, aspirin is the drug that must be avoided to prevent an exacerbation of the patient's respiratory symptoms.

Drugs	Action
Cotrimoxazole	Antibiotic, safe
Co-amoxiclav	Antibiotic, safe
Aspirin	Must be avoided
Chloramphenicol	Antibiotic, safe

In conclusion, the appropriate action is to avoid aspirin in this patient due to the risk of exacerbating asthma symptoms associated with Samter's triad.