Question

A drug is given for the treatment of hyperlipidemia. Facial flushing was noted. Which of the following drug causes this side effect?

• A. Nicotinic acid
• B. Statins
• C. Fibrates
• D. Ezetimibe

Hint:

Facial flushing is a well-known side effect of niacin (nicotinic acid) when used to treat hyperlipidemia, and it can be managed with aspirin.

Answer 1

The Correct Option is A

Solution:
Facial flushing is a common side effect associated with the use of certain drugs used to treat hyperlipidemia. In this context, the drug known to cause facial flushing is Nicotinic acid (also known as Niacin).

The mechanism by which Nicotinic acid causes facial flushing is through the release of prostaglandins. When Nicotinic acid is ingested, it stimulates the production of prostaglandins, which are substances in the body that can cause the dilation of blood vessels. This dilation leads to increased blood flow to the skin, resulting in the sensation of warmth or flushing, typically experienced on the face.

It's important for patients to be aware of this side effect, as it is harmless but can be uncomfortable or alarming if unexpected. In some cases, the flushing can be minimized by taking aspirin 30 minutes before the Nicotinic acid dose.

Drug	Facial Flushing Side Effect
Nicotinic acid	Yes
Statins	No
Fibrates	No
Ezetimibe	No

Therefore, the drug responsible for causing facial flushing in this scenario is Nicotinic acid.