Hemophilia is a genetic disorder that affects blood clotting. It is an X-linked recessive condition, meaning that it is carried on the X chromosome. Males are more commonly affected because they have only one X chromosome. Hemophilia results from deficiencies in clotting factors such as factor VIII (Hemophilia A) or factor IX (Hemophilia B), leading to prolonged bleeding.
List I | List II |
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(A) Radiation hybrid mapping | (I) DNA can be cut into large fragments and circularized for use in chromosome walking |
(B) Sequence tagged site (STS) mapping | (II) Useful for cloning of overlapping DNA fragments (restricted to about 200 kb) |
(C) Chromosome jumping | (III) Fragment genome into large pieces and locate markers and genes |
(D) Chromosome walking | (IV) Applicable to any part of DNA sequence if some sequence information is available |