Question

A 42-year-old patient with obstructive jaundice. Alp, Ggt, haptoglobin all increased. The most likely cause is:

• A. Alcohol
• B. Lead
• C. Chronic rf
• D. None of the above

Answer 1

The Correct Option is A

The question involves a 42-year-old patient experiencing obstructive jaundice with increased levels of Alkali Phosphatase (ALP), Gamma-Glutamyl Transferase (GGT), and haptoglobin. To deduce the most likely cause from the given options, we need to evaluate the implications of these elevated markers in the context of the patient's condition.

• Alkali Phosphatase (ALP) and Gamma-Glutamyl Transferase (GGT): Both are enzymes that are frequently elevated in liver disease. ALP is commonly increased in bile duct obstruction, and GGT increases in liver disease, particularly with alcohol use.
• Haptoglobin: This protein binds free hemoglobin released from erythrocytes. An increase can indicate liver disease or inflammation.

Analysis of Options:

• Alcohol: Chronic alcohol use leads to liver damage, often causing an increase in ALP and GGT levels, consistent with obstructive jaundice symptoms and the enzyme profile described.
• Lead: Typically associated with anemia or neurological issues, but not specifically linked to the enzyme profile here.
• Chronic RF (Renal Failure): Could affect haptoglobin levels but doesn't match the liver enzyme findings.
• None of the above: Is ruled out since the symptomatology fits well with one provided option (alcohol).

Considering the explanations, the most likely cause of the patient's condition is related to Alcohol consumption, which aligns with the increases in liver function tests observed.