Question

A 33-year-old man presents with a 5-week history of calf pain, swelling, and lowgrade fever. Serum levels of creatinine kinase are elevated. A muscle biopsy reveals numerous eosinophils also she had peripheral blood eosinophilia. Which of the following interleukins is primarily responsible for the increase in eosinophils in this patient?

• A. IL2
• B. IL4
• C. IL1
• D. IL6

Answer 1

The Correct Option is B

The condition described in the problem suggests eosinophilia associated with an inflammatory response. Eosinophils are a type of white blood cell that increases in number during certain inflammatory or allergic conditions. A key mediator known to increase eosinophil production is the cytokine interleukin 4 (IL4). IL4 plays a role in the differentiation of naive helper T cells to Th2 cells, which is imperative in the immune response leading to eosinophilia.
In the context of the given options:

• IL2: Primarily involved in the growth and proliferation of T cells.
• IL4: Crucially involved in the stimulation of B cell proliferation and eosinophil growth and differentiation.
• IL1: Functions mainly in the activation of the inflammatory response and fever.
• IL6: Involved in inflammation and the acute phase response.

The elevation in eosinophils observed in the patient is best explained by the action of IL4, making it the correct choice responsible for the increase in eosinophils.