Step 1: Observe the given numbers: \(4, 9, 16, 25, ?, 49\).
Step 2: Recognize the pattern as perfect squares:
\[
4 = 2^2, \quad 9 = 3^2, \quad 16 = 4^2, \quad 25 = 5^2, \quad ? = 6^2, \quad 49 = 7^2
\]
Step 3: Calculate the missing term:
\[
6^2 = 36
\]
Therefore, the missing number is 36.