Question

10-year-old male presents with cervical lymphadenopathy, Surface Ig+, CD34-, CD5-, CD23-, Tdt-, CD10+, CD19+:

• A. Burkitt's Lymphoma
• B. Diffuse Large B-cell Lymphoma (DLBCL)
• C. Anaplastic Large Cell Lymphoma (ALCL)
• D. B-cell Acute Lymphoblastic Leukemia (B-ALL)

Hint:

Burkitt's lymphoma is often associated with rapid lymph node enlargement and positive markers like CD10 and CD19.

Answer 1

The Correct Option is A

The clinical presentation and immunophenotype provided match Burkitt's Lymphoma. Let's break down the key features supporting this diagnosis:

The question describes a patient as a 10-year-old male with cervical lymphadenopathy and a very specific immunophenotype: Surface Ig+, CD34-, CD5-, CD23-, Tdt-, CD10+, CD19+.

1. Surface Ig+: Indicates the presence of surface immunoglobulin, characteristic of mature B-cell neoplasms.
2. CD34-: CD34 is a marker of hematopoietic progenitor cells. Its absence suggests a mature lymphoid cell rather than an immature blast.
3. CD5- and CD23-: The absence of these markers rules out Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL), which typically express one or both.
4. Tdt-: Terminal deoxynucleotidyl transferase (TdT) is a marker of lymphoid progenitor cells. Its absence further suggests that the cells are mature B cells.
5. CD10+ and CD19+: These are markers found on certain B-cell lymphomas and leukemias. CD10 is often associated with germinal center B-cells, relevant for Burkitt's Lymphoma.

This immunophenotypic pattern aligns with Burkitt's Lymphoma, a mature B-cell lymphoma characterized by high proliferative activity and often presenting with abdominal or cervical masses in children.