Question

Zidovudine is an analogue of

• A. Thymidine
• B. Cytidine
• C. Purine
• D. Guanosine

Hint:

Zidovudine was one of the first drugs approved for HIV treatment and works by interfering with the virus's ability to replicate its genetic material.

Answer 1

The Correct Option is A

Zidovudine, also known as AZT, is a nucleoside analogue used as an antiretroviral drug to treat HIV. It mimics the structure of thymidine, a nucleoside that is a building block of DNA. Zidovudine is incorporated into viral DNA by HIV's reverse transcriptase enzyme, but it lacks a functional 3'-hydroxyl group, which prevents further DNA chain elongation, thus inhibiting viral replication. It is specifically an analogue of thymidine, not cytidine, purine, or guanosine.
Thus, the correct answer is Thymidine.