The hypothesis that the first form of life could have originated from pre-existing non-living organic molecules was proposed by Alexander Oparin and John Haldane.
Oparin, in 1924, and Haldane, in 1929, independently suggested this concept, which later became known as the Oparin-Haldane hypothesis of abiogenesis. They hypothesized the early Earth had a reducing atmosphere composed of methane, ammonia, hydrogen, and water vapor. Under these conditions, with the addition of energy such as lightning or ultraviolet light, simple organic compounds could form.
Over time, these organic molecules could have undergone further complex reactions eventually leading to the formation of life. This hypothesis laid the groundwork for future experiments, like the Miller-Urey experiment, which aimed to recreate these primitive Earth conditions to provide evidence for abiogenesis.