Step 1: Understanding niacin and its role. Niacin, also known as Vitamin B3, is essential for the proper functioning of the body's metabolic processes. It plays a key role in energy production and the repair of DNA.
Step 2: Niacin deficiency and Pellagra. Pellagra is caused by a deficiency of niacin or its precursor tryptophan. Symptoms of pellagra are commonly referred to as the "3 Ds":
- Dermatitis (skin issues, especially in sun-exposed areas),
- Diarrhea,
- Dementia, and if untreated, it can lead to death.
Step 3: Why other options are incorrect. - Anemia is caused by deficiencies in iron, Vitamin B12, or folate. - Night blindness is due to Vitamin A deficiency. - Scurvy results from a lack of Vitamin C.
Match the following Class and their Drug:
(1) Alkylating (P) 5-fluorouracil
(2) Platinum analog (Q) Cisplatin
(3) Antimetabolite (R) Cetuximab
(4) EGF receptor inhibitor (S) Chlorambucil