Lactic acid is known to increase extracellular potassium (K+) concentration. Epinephrine, also known as adrenaline, can cause an increase or decrease in extracellular K+ depending on the dose and the specific physiological conditions. In general, epinephrine has a tendency to increase extracellular K+. Glucagon has a tendency to increase extracellular K+. Atropine, which is a muscarinic acetylcholine receptor antagonist, can cause a decrease in extracellular K+. It's important to note that the exact effect of these substances on extracellular K+ can be influenced by various factors such as dose, duration, and overall physiological state of the organism.