Step 1: Analyze the types of reproduction in Amoeba.
Amoeba reproduces asexually through binary fission. In this process, the cell divides into two identical daughter cells, each with a full set of chromosomes. This is the most common mode of reproduction in unicellular organisms like Amoeba.
Step 2: Review the options.
- Fragmentation: This is a form of reproduction where an organism breaks into pieces, each of which grows into a new organism, but it is not common in Amoeba.
- Multiple fission: While some organisms may use this method, Amoeba generally uses binary fission rather than multiple fission.
- Budding: This type of reproduction occurs in some organisms, like yeast, but not in Amoeba.
- Binary fission: This is the correct process by which Amoeba divides into two identical daughter cells.
Step 3: Conclusion.
Therefore, the correct answer is (D) Binary fission.
Final Answer:
\[
\boxed{Binary \; fission}
\]